Serum biochemical changes following constant rate infusion of Ketoprofen and Ketoprofen + Tramadol combination in laparotomized dogs

Abstract

There is no data on safety of ketoprofen and ketoprofen + tramadol combination by constant rate infusion for the management of laparotomy-induced pain. The study investigated the serum biochemical changes associated with the use of ketoprofen and ketoprofen + tramadol combination by constant rate infusion in laparotomized dogs. Fifteen adult female Nigerian mongrels were randomly assigned into three groups (n = 5). Group 1 was treated with normal saline; group 2 received 1.0 mg/kg/h K while group 3 received KT at 0.5 mg/kg/h each. Ventral midline was performed on all dogs post administration of the treatments. Serum activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphotase (ALP), and serum levels of creatinine, urea and total protein were assayed pre-surgery and on post-surgical days (PSD) 1, 3 and 7 following standard procedures. Mean ALT and ALP activities did not differ significantly (p > 0.05) between groups. The mean AST activity of group 2 dogs was significantly higher (p 0.05) between groups. Constant rate infusion of Ketoprofen and Ketoptofen + Tramadol led to no clinically significant abnormality in the serum biochemistry of laparotomized dogs and could be recommended for the management of post-surgical pain.