Abstract
Abstract Aim To investigate whether atrial natriuretic peptide (ANP) level is altered in polycystic ovarian syndrome (PCOS) patients with clomiphene citrate (CC) resistant and whether it correlates with insulin sensitivity markers. Methods Serum ANP, insulin and glucose levels and the homeostasis model assessment for insulin resistance index (HOMA-IR) were evaluated among a group of PCOS women with CC resistance (n = 40). A control group (n = 30) was selected from healthy women with regular menstrual cycles. Results Serum ANP level was significantly lower in the study group than in the control group (0.74 ± 1.1 ng/ml vs 3.17 ± 1.9 ng/ml; P Conclusion The PCOS patients with CC resistant have reduced plasma ANP level and increases HOMA-IR index compared with healthy regular menstruating women. Low serum ANP level may be involved in the metabolic features of CC resistant PCOS.
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