Abstract
IntroductionPropolis is a natural product with many biological activities. The present study was designed to evaluate the effects of Chinese propolis on glucose metabolism, antioxidant function, and inflammatory cytokines in patients with type 2 diabetes mellitus (T2DM).MethodsIn the 18-week study, recruited T2DM patients were randomly divided into a Chinese propolis group (900 mg/day) (n = 31) and a control group (n = 30) according to fasting serum glucose levels at baseline.ResultsAt the end of the study, no significant difference was found between the groups in serum glucose, glycosylated hemoglobin, insulin, aldose reductase, or adiponectin. However, serum GSH, flavonoids, and polyphenols were significantly increased, and serum lactate dehydrogenase activity was significantly reduced in the Chinese propolis group. Meanwhile, serum IL-6 was significantly increased in the Chinese propolis group.ConclusionChinese propolis is effective at improving antioxidant function in T2DM patients, partly by increasing serum antioxidant parameters.
Highlights
Propolis is a natural product with many biological activities
We found that Brazilian green propolis improved antioxidant function and modulated inflammatory cytokines in type 2 diabetes mellitus (T2DM) patients after an 18-week intervention
Six patients from the Chinese propolis group withdrew from the study because of allergies to Chinese propolis or for personal reasons
Summary
The present study was designed to evaluate the effects of Chinese propolis on glucose metabolism, antioxidant function, and inflammatory cytokines in patients with type 2 diabetes mellitus (T2DM). Diabetes Ther (2018) 9:101–111 or delay the occurrence of diabetic complications in diabetic rats [2, 9, 10] We showed that both Chinese and Brazilian green propolis decreased the serum glucose level and improved antioxidant function in rats with DM [11]. We found that Brazilian green propolis improved antioxidant function and modulated inflammatory cytokines in T2DM patients after an 18-week intervention. The study reported in the present paper aimed to investigate the effects of Chinese propolis on glucose metabolism, antioxidant function, and inflammatory cytokines in patients with T2DM
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