Abstract
Objective The authors investigated the association between serum anticholinergic activity (SAA) and cognitive performance in a group of patients with moderate-to-severe dementia. Methods SAA and cognitive performance were assessed in 26 patients admitted to a geropsychiatric unit for the treatment of behavioral disturbances associated with dementia. SAA was measured by radioreceptor competitive binding assay. Cognition was tested with the Mini-Mental State Exam and the Severe Impairment Battery. Results Higher SAA was associated with lower cognitive performance. Conclusions This study extends to patients with moderate-to-severe dementia the finding that higher SAA is associated with lower cognitive performance. The authors investigated the association between serum anticholinergic activity (SAA) and cognitive performance in a group of patients with moderate-to-severe dementia. SAA and cognitive performance were assessed in 26 patients admitted to a geropsychiatric unit for the treatment of behavioral disturbances associated with dementia. SAA was measured by radioreceptor competitive binding assay. Cognition was tested with the Mini-Mental State Exam and the Severe Impairment Battery. Higher SAA was associated with lower cognitive performance. This study extends to patients with moderate-to-severe dementia the finding that higher SAA is associated with lower cognitive performance.
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