Abstract
Serum haemagglutinating antibodies to 9 strains of streptococci and 2 of lactobacilli were determined in 47 subjects. These were divided into a group with a high D.M.F. index (mean 16) and another with a low D.M.F. (mean 3). Haemagglutinating antibodies were detected to all bacteria tested and in most sera from subjects with a high and low caries experience. Antibody levels to Streptococci FA-1 and KIR, cariogenic to animals, and an oral strain of Lactobacillus acidophilus were significantly raised in subjects with a high D.M.F., as compared with those having a low D.M.F. index. The cumulative antibody titre to 7 streptococci, cariogenic to animals, was significantly raised in subjects with a high caries incidence. These immunological results are consistent with the established view of a bacterial pathogenesis of dental caries in man.
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