Serum anti Mullerian hormone levels: A better hormonal marker of ovarian reserve

Abstract

Aim: To determine whether Serum AMH is a better hormonal marker of Ovarian Reserve. Objectives: 1. To correlate AMH with FSH and maternal Age and whether AMH is a better predictor of ovarian response than FSH. Materials & Methods: A total of 246 women enrolled for IVF-ICSI fulfilling the selection criteria were recruited for the study at a tertiary ART centre. On day 3 of the cycle serum AMH, FSH were assayed along with LH, E2, TSH and Prolactin. Within 3 months they were subjected to IVF-ICSI. Serum AMH and FSH levels were compared with Age and Oocytes retrieved. Results: All the 246 women enrolled were analysed. The mean age of the women was 30.7 ± 4.5, average number of oocytes retrieved was 11.8 ±7.1. There was a nega tive correlation of AMH with age (r= -0.28) which is statistically significant where as FSH showed a positive correlation (r= - 0.27). With regard to retrieval of mature oocytes, AMH showed a high positive correlation (r= 0.60) which is statistically signif icant (p <0.000) when compared to serum FSH (r = -0.26). Conclusion: AMH is a better hormonal marker of Ovarian Reserve and a better predictor of Oocytes retrieved than serum FSH levels.