Abstract
Purpose: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that has a serious effect on worldwide public health. We sought relationships among ANGPTL2, ANGPTL3, and ANGPTL6 with NAFLD metabolic and biochemical parameters, to assess their potential as diagnostic tools for NAFLD. Materials and Methods: Serum levels of ANGPTL2, ANGPTL3, and ANGPTL6 in NAFLD patients (n = 52) and non-NAFLD participants (n = 51) were quantified by ELISA. The utility of ANGPTLs as biomarkers for NAFLD prediction was assessed using receiver operating characteristic (ROC) analysis. Results: Serum ANGPTL2 levels were increased (P = 0.0102), serum ANGPTL3 levels were decreased (P Conclusion: ANGPTL2 and ANGPTL3 levels may be novel and important predictors of NAFLD severity.
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