Abstract
Objective. Omentin, a new discovered adipokine, is implicated to inhibit inflammation. Inflammation is one important mechanism of diabetic retinopathy (DR). The purpose of this work was to evaluate serum and vitreous concentrations of omentin-1 in patients with diabetic retinopathy (DR). Methods. This study enrolled 204 diabetic patients (60 without DR, 49 with NPDR, and 95 with PDR) and 65 control subjects. Results. Serum and vitreous omentin-1 levels in PDR patients were markedly decreased compared with those in the other three groups. NPDR patients showed reduced vitreous omentin-1 compared with patients without DR. In addition, control subjects had significantly higher levels of serum and vitreous omentin-1 compared with diabetic patients without DR, NPDR patients, and PDR patients. In addition, serum/vitreous omentin-1 ratio was positively correlated with the development and severity of DR. Conclusion. Serum and vitreous omentin-1 levels, as well as serum/vitreous omentin-1 ratio, are correlated with the presence and severity of DR.
Highlights
Diabetic retinopathy (DR), the most serious diabetic complication, is estimated to account for 4.8% of global blindness [1]
NPDR patients showed reduced vitreous omentin-1 levels compared with type 2 diabetes mellitus (T2DM) patients without diabetic retinopathy (DR)
Serum omentin1 levels were lower in the impaired glucose regulation group than in the normal glucose tolerance (NGT) group [6]
Summary
Diabetic retinopathy (DR), the most serious diabetic complication, is estimated to account for 4.8% of global blindness [1]. Major research has been concentrated on the elucidation of its pathogenesis, the clear mechanism of DR is still unknown. Within the factors involved in the mechanism of DR, inflammation is paid more attention during the past decade [2]. A multitude of inflammatory mediators have been demonstrated to be involved in the mechanism of diabetic retinopathy [3]. Omentin-1, a novel visceral fat depot-specific secretary protein, is produced/synthesized by the visceral stromal vascular cells [4]. Decreased omentin-1 concentrations were found in patients with insulin resistance (IR) [5] and diabetes mellitus [6]. Omentin-1 was demonstrated to play an anti-inflammatory role in vascular smooth cells [7]. Inflammation is correlated with the development of DR
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