Abstract
AbstractAllantoin and uric acid were measured in the urine and serum of virgin rats and reproducing rats at various times during pregnancy and lactation, and in the serum and amniotic fluid of foetuses on the 21st day of pregnancy. Urinary allantoin excretion increased steadily during pregnancy and remained high during the first 20 days of lactation but thereafter declined. Serum allantoin concentrations were higher in pregnant and lactating rats than in virgin rats. Amniotic fluid allantoin concentrations were greater than those of foetal serum, which in turn exceeded the maternal serum values. Uric acid concentrations were lower in serum and much lower in urine than allantoin concentrations in all samples examined.
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