Abstract
The aim of the present study was to investigate the change in the total protein content between the serum and saliva of female patients with breast cancer and in healthy females. The study was conducted between October 2012 and November 2013. There were 80 females in the present study with 40 breast cancer patients and 40 healthy control subjects, with an age range of 50–70 years. The results of the study showed that the mean value ± standard deviation of the total serum protein in patients with breast cancer was 7.63±0.41 g/dl, whereas in the healthy subjects it was 6.14±1.84 g/dl. The total salivary protein measurement was 0.14±0.07 g/dl and 0.25±0.09 g/dl in the breast cancer and healthy group, respectively. Therefore, it can be concluded that the total serum protein was higher in female patients with breast cancer, whereas the levels in the saliva were lower compared to the healthy female group. The results of the present study indicate that serum protein levels may be used for the diagnosis of breast cancer.
Highlights
Proteins play a central role in cell structure and function
The results show that the levels in the serum of the control group compared to those levels in breast cancer patients were 6.14±1.84 and 7.63±SD 0.41 g/dl, respectively (Figs. 1 and 2)
The measurements of the serum total protein revealed that there was an increase in the total protein concentration in the serum of female patients with breast cancer
Summary
The serum contains a mixture of proteins that differ in origin and function, and the amount of protein in the vascular compartment depends on the balance between the rate of synthesis and the rate of catabolism or loss [1]. It is a well‐established and evidence‐based fact that serum protein levels may undergo changes during the process of breast cancer [2]. The aim of the present study was to determine the total protein levels in the saliva and serum from female patients with breast cancer in comparison to the levels in the healthy control group
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