Abstract
Abstract Ceftriaxone and cefazolin concentrations were assayed by high-pressure liquid chromatography in serum and pelvic tissue. Specimens were obtained at uterine removal subsequent to a 1-g intramuscular preoperative dose given to 117 women scheduled for elective vaginal or abdominal hysterectomy. The mean serum concentration of cefazolin was 43.2 ± 13.1 and 39.8 ± 15.4 μg/ml after vaginal and abdominal hysterectomy, respectively. For ceftriaxone they were 59.2 ± 16.8 and 56.1 ± 18.3 μg/ml for vaginal and abdominal hysterectomy, respectively. Mean tissue concentrations of ceftriaxone were 22.5 ± 10.4, 17.4 ± 6.9, 27.9 ± 10.7, and 16.4 ± 6.3 μg/g for vagina, myometrium, fallopian tube, and ovary, respectively, and respective mean tissue concentrations for cefazolin were 15.8 ± 7.6, 14.4 ± 8.5, 15.6 ± 8.0, and 12.4 ± 5.8 pg/g. Pelvic tissue concentrations of cefazolin were similar, but concentrations of ceftriaxone in fallopian tube and vagina were higher than those in ovary and myometrium. Tissue to ser...
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