Abstract
Background and Aims : Altered cerebral cholesterol homeostasis is associated with Alzheimer’s Disease (AD). We previously demonstrated higher cerebrospinal fluid (CSF) PCSK9 levels in AD patients compared to controls. This study evaluated the concentrations of PCSK9 in CSF/serum of patients with different degrees of cognitive impairment. We further measured CSF/serum concentrations of the cholesterol metabolites 24-, 25- and 27-hydroxycholesterol (OHC).
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