Abstract
Cervical cancer is one of the most common women cancers. The tumor screening by nurse care is efficacy for cancer prevention. Serum amyloid A1 (SAA1) has shown to be associated with cervical cancer malignancy. The detail information for SAA1 in cervical cancer has not yet been investigated. IL-1 was performed to induce cervical cancer cell lines. Subsequently, SAA1 was silenced or overexpressed in c-33A respectively. The data showed that the expression levels of SAA1 were increased in IL-1 induced cervical cell lines. Downregulation of SAA1 reduced cell proliferation, migration and invasion in c-33A cells, whereas overexpression increased, indicating that SAA1 is a tumor promoter in cervical cancer. Also, SAA1 positively regulates the expression of MMP2, MMP7 and MMP9, which is associated with extracellular matrix reproduction. Furthermore, NF- B inhibitor, SC75741, reversed the effects of SAA1 in cervical cancer, revealing that it might be a potential mechanism for SAA1 in cervical cancer. Therefore, SAA1 is a potential biomarker for cervical cancer in the inflammatory microenvironment.
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