Abstract
The present study has been carried out mainly to study the sequential changes of serum alpha-fetoprotein (AFP) levels with the evolution of experimental hepatocellular carcinoma (HCC) and to correlate with the histology of the tumors. Rats fed with 0.06% of azodyes developed HCC by 8–24 months and on the basis of their capacity to synthesize AFP, the animals can be divided into two distinct major groups—“quick responders” and “slow responders”. In the first group the animals developed tumors by 8–10 months and mostly of poorly differentiated type with high serum AFP levels. The slow responders developed tumors only after 16 months and they were mostly of well differentiated with comparatively low AFP values. Both the groups showed biphasic response of AFP during the evolution of HCC. The animals in aflatoxin B 1 group did not show AFP levels more than 2μ g/ml.
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