Serum alpha-1-antitrypsin level in Iraqi patients with coronary heart disease

Asmaa M Salih

doi:10.24126/jobrc.2011.5.1.147

Abstract

This study was designed to estimate the level of serum alpha -1- antitrypsin in patients with coronary heart disease. Patients were clinically subdivided into stable angina 25 patients, unstable angina30 patients and myocardial infarction 50 patients. A control sample of 30 individuals was matched with patient for age and sex.Non-significant elevation of serum alpha one antitrypsin were noted in MI cases compared to healthy control individuals, even some MI patients showed decreasing level of alpha one antitrypsin, which may return to hereditary alpha one antitrypsin deficiency in Iraqi patients.The Stable angina patients group showed non-significant decrease in alpha one antitrypsin level compared to healthy control, while unstable angina patients group showed significant decrease in alpha one antitrypsin level that will may facilitate developing disease towards MI. All present results need additional studies to be carried out on larger samples of Iraqi individuals and alpha one antitrypsin deficient patients, furthermore, highlighting on the relationship between alpha one antitrypsin and risk of coronary heart disease.

Highlights

This study was designed to estimate the level of serum alpha -1- antitrypsin in patients with coronary heart disease
Table (1) shows the mean level of Alpha 1- antitrypsin (AAT) concentration in patient groups and healthy control, the myocardial Infarction (MI) group had the highest mean (1.367 ± 0.450) with no significant differences compared to healthy control (1.332 ± 0.581),While S.A group
Present result agrees with recent report, that a high level of AAT was observed more often in patients with MI than in those with Un.A [3], while, present data disagrees with the previous study, which recorded a significant elevations of serum AAT in MI and angina cases [4]