Abstract
Depression is one of the most prevalent mental disorders and one of the main causes of disability worldwide...
Highlights
Prediction and evaluation of the efficacy of pharmacotherapy of depression is a problem of current importance
The aim of the study was to investigate the kinetics of tryptophan fluorescence decay in serum albumin of patients with melancholic depression (MD) using subnanosecond fluorescent spectroscopy
In human serum albumin (HAS) excitation at >295 nm is absorbed mainly by tryptophan 214 (Trp-214) residues excitation in the range of 295 - 305nm permits to observe the state of its environment
Summary
Prediction and evaluation of the efficacy of pharmacotherapy of depression is a problem of current importance. All this call forth the necessity of the development of objective methods for the individual prediction of the efficacy of medication on the early stages of antidepressant therapy. There are 3 fluorescent amino acid residues in human serum albumin (HAS) - tryptophan, tyrosine and phenylalanine. In HSA excitation wavelength at 295 - 305 nm is mainly absorbed by tryptophan-214 residues (Trp214-R) that as inner probe of albumin molecules gives possibility of selective observation of state of albumin molecule and possible conformational changes [4]. The aim of the study was to investigate the kinetics of tryptophan fluorescence decay in serum albumin of patients with melancholic depression (MD) using subnanosecond fluorescent spectroscopy
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