Abstract
Serum albumin conformation in patients with melancholic depression under antidepressant therapy
Highlights
IntroductionThere were investigated 22 patients with melancholic depression (dep) (14 women and 8 men)
There were investigated 22 patients with melancholic depression (14 women and 8 men)
Patients with melancholic depression (MD) were investigated in dynamics of antidepressant therapy: at admission, on 15th and 30th days of treatment
Summary
There were investigated 22 patients with melancholic depression (dep) (14 women and 8 men). Patient’s state according to ICD-10 criteria was defined as a depressive episode in the frame of bipolar depressive disorder (type 2) (F32) and in the structure of recurrent depressive disorder (F33). Patients with MD were investigated in dynamics of antidepressant therapy (venlafaxine - 75-150 mg/daily): at admission, on 15th and 30th days of treatment. Control group (con) consisted of 54 volunteers. Investigation was performed in accordance with the permission of the local ethical committee of Moscow Research Institute of Psychiatry (N 16, 13.03.2017). Sub nanosecond laser time resolved fluorescence spectroscopy (SLTRFS) with K-35 fluorescent probe (dimethylaminonaphthalic acid N-carboxyphenylimide, CAPIDAN) was used for the investigation of albumin conformation
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