Abstract
Objective:-Myocardial infarction is characterised by widespread irreversible cellular necrosis & death due to ischaemic injury.Atherosclerotic plaques & their role in bringing about ischaemic injury forms an integral component of the pathogenesis of myocardial infarction.An immune link in the formation of atherosclerotic plaques has been reported by few researchers.The enzyme adenosine deaminase is a key player in the immune system.This study intends to estimate adenosine deaminase(ADA) activity in serum,Troponin I & other cardiac enzymes in patients with myocardial infarction. Methods:-The study comprised of 40 patients with myocardial infarction alongwith 20 age & sex matched healthy controls.Serum ADA,Troponin I & cardiac enzymes [CPK-MB,LDH,AST] were estimated. Results:- An appreciable rise in serum ADA activity was observed alongwith elevated titres of cardiac enzymes & Troponin I in patients with myocardial infarction. Conclusion:- ADA is a key player in immune system & is a marker of T-lymphocyte activation.Raised titres of ADA in myocardial infarction patients as was observed in this study provide evidence in favour of T-lymphocyte activation & proliferation in myocardial infarction thereby opening a new dimension in understanding of the pathogenesis of myocardial infarction.This nding also suggests possible use of serum ADA activity as a marker in elucidating the pathogenesis of myocardial infarction
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