Abstract
Anti-acetylcholine receptor (AchR) antibodies in 19 non-myasthenic and 9 myasthenic sera were determined by radioimmunoassay, using [ 125I]α-bungarotoxin-complexed receptors of human and denervated rat muscles (standard assay). Anti-AchR antibodies in the same sera blocked by antihuman IgG were assayed in parallel to measure background radioactivity (blank assay). The activity of blank assay did not differ significantly from that of standard assay in non-myasthenic sera. There was no remarkable difference in blank assay titers between non-myasthenic and myasthenic sera. The corrected titers, obtained by subtracting blank assay titers from standard assay titers, were in excess of those of non-myasthenic sera in 6 of 9 myasthenic sera with the denervated rat AchR and 8 of 9 myasthenic sera with human AchR. These findings suggest that this method is useful for the detection of the anti-AchR antibody in myasthenic sera.
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