Abstract
BackgroundVitamin D deficiency is associated with heightened risk of cardiovascular disease. Potential mechanisms include involvement of vitamin D in regulation of renin-angiotensin system and manufacture and secretion of cardiac natriuretic peptides. Our aim was to document relationships between 25 hydroxyvitamin [25(OH)D] and N-terminal pro B-type natriuretic peptide (NT-proBNP) and plasma renin activity (PRA) levels and to document the effect of vitamin D administration on NT-proBNP and PRA levels in vitamin D deficient subjects.MethodsSerum 25(OH)D, parathyroid hormone (PTH), plasma or serum NT-proBNP and PRA levels were measured at baseline in nulliparous and lactating women and after 2 months of oral vitamin D2 (2,000 IU/day or 60,000 IU/month) supplementation to lactating women.ResultsBaseline levels of 25(OH)D were low (<50 nmol/L) in most women whereas PRA and NT-proBNP levels were within the normal range. There were no significant correlations between baseline 25(OH)D or PTH with NT-proBNP and PRA. Vitamin D administration over a 2-month period in lactating women was associated with a decline in NT-proBNP (by 9.1 ± 2.0 pmol/L; p < 0.001) and PRA (by 0.32 ± 0.17 nmol/L/hr; p = 0.064). However, there were no significant correlations between the changes from baseline in 25(OH)D and either NT-proBNP (r = -0.04, p = 0.8) or PRA (r = -0.04, p = 0.8).ConclusionWe found no significant correlations between 25(OH)D or PTH with NT-proBNP and PRA in vitamin D deficient women. Further information is required to clarify the effects of vitamin D administration on cardiac structure and function.
Highlights
Vitamin D deficiency is associated with heightened risk of cardiovascular disease
In some Arab countries, vitamin D deficiency is common especially amongst women [14,15], and it has been proposed that correction of low vitamin D status in such a cohort might reduce the incidence of cardiovascular disease, especially heart failure [16]
Our results show no significant correlations between baseline 25(OH)D concentrations and NT-proBNP levels in vitamin D deficient nulliparous women or between baseline 25(OH)D concentrations and NT-proBNP and plasma renin activity (PRA) in vitamin D deficient lactating women
Summary
Potential mechanisms include involvement of vitamin D in regulation of renin-angiotensin system and manufacture and secretion of cardiac natriuretic peptides. Our aim was to document relationships between 25 hydroxyvitamin [25(OH)D] and N-terminal pro B-type natriuretic peptide (NT-proBNP) and plasma renin activity (PRA) levels and to document the effect of vitamin D administration on NT-proBNP and PRA levels in vitamin D deficient subjects. Vitamin D deficiency has been linked with heightened risk of hypertension and cardiovascular disease [4,5,6,7,8]. Potential mechanisms that may explain this link include involvement of vitamin D in the regulation of the renin-angiotensin system [9,10,11], and (page number not for citation purposes).
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