Serum 25‐hydroxy vitamin D is associated with blood total cholesterol and diastolic blood pressure in a young multi‐ethnic group living in South Florida (1041.15)

Abstract

Objective: The aim of this study was to investigate the relationship between serum 25‐hydroxy vitamin D, total cholesterol and blood pressure (BP) among young multi‐ethnic participants living in South Florida.Methods: This cross‐sectional study included 80 young adults, males (n=42) and females (n=38), ages 18‐36 years recruited from Florida International University campus. Serum 25‐hydroxy vitamin D and TC were measured by ELISA method. Systolic and diastolic BPs were measured by an automated monitor. Weekly total sun exposure and daily vitamin D intake were calculated from validated sun exposure and food frequency questionnaires respectively. A multi‐linear regression model was run, adjusting for age, gender, body mass index, systolic BP, daily vitamin D intake, total weekly sun exposure and tobacco use.Results: Total cholesterol (P= 0.020) and diastolic blood pressure (P= 0.025) were negatively associated with serum 25‐hydroxy vitamin D. This association remained significant after controlling for covariates (B= ‐0.074, P=.045 for total cholesterol, B= ‐0.421, P= ‐0.018 for diastolic blood pressure). The model explained 18.4% of the variation in serum 25‐hydroxy vitamin D.Conclusion: The results of this study suggest that high total blood cholesterol and diastolic blood pressure may be associated to low serum 25‐hydroxy vitamin D level. Interventions are needed to confirm these results.Grant Funding Source: Supported by NIH/NIDDK sponsored grant.