Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus

Seham E Abdelsadek,Sabah I Abdel Raheem,Entesar O El Saghier

doi:10.1186/s41983-018-0036-9

Seham E Abdelsadek, Sabah I Abdel Raheem + Show 1 more

Open Access

https://doi.org/10.1186/s41983-018-0036-9

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Abstract

BackgroundSome clinical studies demonstrated a significant association between vitamin D deficiency and diabetic peripheral neuropathy (DPN).ObjectiveThis study aims to evaluate the correlation between serum levels of 25(OH) vitamin D and DPN in Egyptian patients with type 2 diabetes mellitus (T2DM).Patients and methodSixty patients were known to have T2DM, which classified into the following: group I included 40 patients with DPN and group II included 20 diabetic patients, without DPN, compared with 30 apparently healthy subjects of matched age and sex as control group. Laboratory investigations including fasting and 2-h postprandial blood glucose levels, serum calcium, phosphorus, glycosylated hemoglobin (HbA1c), lipid profile, serum 25(OH) vitamin D, and nerve conduction studies were carried out for every participant to detect the existence and severity of DPN.ResultsVitamin D deficiency was found in 73.3% of T2DM groups and in 35% of control subjects with statistical significant differences (p < 0.005), and serum level of 25(OH) vitamin D in patients with DPN (21.09 ± 8.38) was less statistically significant than that in patients without DPN (31.12 ± 14.85) (p = 0.001). Mean serum level of 25(OH) vitamin D in patients with painless DPN (10.047 ± 8.12) was less significant than that in patients with painful DPN (18.14 ± 3.85), (p < 0.05). Regression analysis revealed that vitamin D deficiency is one of the independent risk factors of DPN, (OD, 0.914), (p = 0.007).ConclusionVitamin D deficiency has a significant role in the development and severity of DPN in Egyptian patients with T2DM.

Highlights

The most common cause of peripheral neuropathy in Egypt is diabetes mellitus (DM)
Vitamin D deficiency has a significant role in the development and severity of diabetic peripheral neuropathy (DPN) in Egyptian patients with type 2 diabetes mellitus (T2DM)
Mean serum levels of FBG, PPBG, total cholesterol, LDL, and body mass index (BMI) were significantly higher among T2DM patients group than control group (p < 0.001), but serum HDL and TG had no significant difference (p > 0.05)

Summary

Introduction

The most common cause of peripheral neuropathy in Egypt is diabetes mellitus (DM). Diabetic peripheral neuropathy is one of microvascular complications that causes morbidity and mortality in patients with diabetes mellitus; 50% of diabetic patients have diabetic neuropathy [1]. DPN complications are foot amputation due to painless. Abdelsadek et al The Egyptian Journal of Neurology, Psychiatry and Neurosurgery (2018) 54:36 with vitamin D deficiency, and neuropathic pain symptoms [8], neurological deficits, autonomic dysfunction [9], and electrophysiological studies in diabetic patients [10], a prospective clinical study reported the improvement of neuropathic pain in DPN patients with vitamin D supplementation [11]. Some clinical studies demonstrated a significant association between vitamin D deficiency and diabetic peripheral neuropathy (DPN)

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