Abstract
BackgroundThis study aimed to examine the relationship between 25-hyfromxyvitamin D (25OHD) and chronic kidney disease (CKD) incidence.MethodsAll the elderly who had participated both in the 2011–2012 survey and 2014 survey in the Chinese Longitudinal Healthy Longevity Survey (CLHLS), and have biomarker data were included in the analysis. We studied those without CKD with complete data at 2011–2012 waves. Serum 25-Hydroxyvitamin D was assessed at baseline. Cox proportional risk model was used to evaluate associations between serum 25-Hydroxyvitamin D and CKD (including both albuminuria and impaired eGFR) incidence after adjusted for potential confounding..ResultsDuring the follow-up years, 255 incident cases of CKD were diagnosed. Those who developed CKD had relatively lower serum 25(OH)D (mean 37.63 vs.51.36 nmol/L, p < 0.001) compared with those who remained free of CKD. Each 1 nmol/L increase in 25(OH)D was associated with 3.4% reduced risk of CKD (HR = 0.966, 95%CI: 0.959–0.973) after adjusted for related covariates. The HRs of each 1 nmol/L increase in 25(OH)D for albuminuria and impaired eGFR were 0.952(95%CI: 0.941–0.963) and 0.975(95%CI: 0.966–0.983) respectively. When use the classifications (sufficiency, insufficiency, deficiency) or quintiles of baseline 25(OH)D levels in the Cox model, the corresponding HRs showed an increasing trend along with the decrease of baseline 25(OH)D levels (p for trend < 0.001).ConclusionsHigher 25(OH)D levels were inversely and independently associated with CKD incidence among Chinese elderly. The trend for the observed linear relationship b was most pronounced among the lowest quintile.
Highlights
This study aimed to examine the relationship between 25-hyfromxyvitamin D (25OHD) and chronic kidney disease (CKD) incidence
Incidence of CKD according to baseline 25(OH)D level There were a total of 255 CKD cases during the 21,586 person-years
The total three years’ incidence was 24.6% (95%CI: 22.0–27.2%). For those who were of vitamin D deficiency or insufficiency (50-75 nmol/L) at baseline, the CKD incidence was 32.7% (95%CI: 29.0–36.4%) and 14.2% (95%CI: 10.4–18.0%) respectively
Summary
This study aimed to examine the relationship between 25-hyfromxyvitamin D (25OHD) and chronic kidney disease (CKD) incidence. Vitamin D is a pro-steroid hormone, and first hydroxylated to 25 (OH) D in the liver, and further hydroxylated to 1,25(OH)2D in the renal proximal convoluted tubules. The widespread recognition of vitamin D was its regulation of calcium and phosphorus metabolism. It has been found that vitamin D has a wide range of metabolic and cell. Chronic kidney disease (CKD) is one of the most important diseases which affect about 10–15% of adults. Epidemiological data showed that the prevalence of CKD increase for the past 20 years [7, 8]. Compared with cardiovascular diseases and diabetes, people have not paid sufficient attention to CKD. Most of the patients went to the hospital when they had appeared clinical symptoms or
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