Serum 25-Hydroxyvitamin D level in Restless Legs Syndrome: A controlled study

Abstract

Objective: We aimed to investigate 25-hydroxyvitamin D (25-OHD) level on a group of restless legs syndrome (RLS) patients. Material and Methods: Twenty-one RLS patients and fourteen age and gender healthy controls (non RLS) with similar age and gender were included in the study. All patients underwent a physical examination for the neurologic and musculoskeletal system. The 25-OHD level was measured for all participants. Results: The 25-hydroxyvitamin D levels were higher in the RLS patient group (20.06±8.79 ng/ml) than in the healthy control group (14.75±4.67 ng/ml). In the healthy control group ‘’without the RLS syndrome’’, 25-hydroxyvitamin D levels were below the normal range (<20 ng/ml). However, there were no statistical differences in terms of vitamin D level between the RLS and Control groups (p>0.05). Conclusion: In this study, due to the absence of RLS syndrome in the control group despite low 25-hydroxyvitamin D levels (<20 ng/ml), a relationship could not be established between 25-hydroxyvitamin D levels and RLS syndrome. The cause of RLS syndrome does not seem to depend on a single parameter such as 25-OHD level.