Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar.

Hanaa Mousa,Vijay Ganji,Susu M Zughaier,Nazmul Islam

doi:10.3390/nu13010127

Abstract

Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12–20 ng/mL (insufficiency), and ≥20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris.

Highlights

The classical function of vitamin D is to maintain the homeostasis of calcium and phosphorous
Al-Dabhani reported that 64% of the population in Qatar suffers from vitamin D deficiency [3]
Monocyte percentage was significantly higher in participants with vitamin D deficiency compared to sufficiency

Summary

Introduction

The classical function of vitamin D is to maintain the homeostasis of calcium and phosphorous. Vitamin D can be obtained from the diet and skin exposure to the sun’s UVB light. Regardless of the source, in the liver, vitamin D is converted to 25-hydroxyvitamin. In the kidney, 25(OH)D is converted to 1,25 dihydroxyvitamin D (1,25(OH) D) by 25-hydroxyvitamin D-1α-hydroxylase [1]. Low circulating concentrations of 25(OH)D is highly prevalent in Qatar. Previous studies conducted in 2012 reported an estimated 90% of the Qatari population suffer from various degrees of vitamin D insufficiency and deficiency [2]. Al-Dabhani reported that 64% of the population in Qatar suffers from vitamin D deficiency [3]

Methods

Results

Conclusion