Abstract

Serum γ-glutamyl transpeptidase (GGTP) activity was elevated in three-quarters of seventy-six anicteric alcoholics or heavy drinkers, 44 of whom (58%) were ambulant out-patients without clinical evidence of liver disease. Transaminase elevation was observed in less than one third, and alkaline phosphatase elevation in less than one tenth. GGTP was the only enzyme elevated in the group classified as heavy drinkers rather than alcoholics. GGTP determination is methodologically simple ; its measurement is considered to be a sensitive and highly specific test for the detection of liver cell injury in the suspected alcoholic and to be superior to transaminase determination for this purpose.

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