Serum α–Amylase Level in Sudanese Patients withLong Standing Diabetes Mellitus Type 2 in Khartoum State,Central Sudan

Abstract

Objectives: To evaluate and correlate the serum activity of ?-amylase in Sudanese patients with type 2 longstanding diabetes mellitus.Methodology: This is a descriptive, cross- sectional, hospital based, case- control study was done in fiftypatients (twenty male &thirty female) above forty yearswith long period diabetes mellitus type 2 referredto Jabber Abu ElizDiabetes Center and Bahri Diabetes Center in Khartoum state in central Sudan withinsix months. Thirty healthy volunteers with matching age and sex and socioeconomic status were included.Data was collected through, clinical evaluation form, questionnaire, and laboratory investigations. Serumconcentrations of ?- amylasewere measured by spectrophotometer and t test and correlation were used instatistical analysis for the comparison between test and control group for example: control group.Results: The result showed a significant difference between the mean of serum ?- amylase of the controlgroup compared with that of the test group (Mean ±SD): (39.83±9.0) versus (32.22±13.5) U/L respectively,(P<0.05). Also, there wasa significant positive correlation between the levels of ?- amylase and the durationof diabetes mellitus. Correlation coefficient (r) = (r = 0.27, P= 0.000) for example: 0.0000.Conclusion: From this study it was concluded that; the diminution of the serum levels of ?- amylase couldbe part of the exocrine pancreatic insufficiency since ?- amylase activity decline correlated well with theduration of long-standing type 2 Diabetes Mellitus.