Abstract
A survey using immunodiffusion techniques for the detection of α 1-feto-protein in 262 adult patients with various types of liver disease revealed the presence of the protein in 14 out of 35 patients with hepatocellular carcinoma; α 1-fetoprotein was absent in all the other patients. Analysis on the basis of geographic localities of origin of the positive patients showed that 5 out of 17 were of British origin, 5 out of 8 of West African origin, and 4 out of 10 from other regions. These results, taken in conjunction with other surveys, suggest that regional differences may exist in the frequency of positive tests in patients with hepatocellular carcinoma.
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