Abstract
Depression is a common disorder amongst the general population and frequently encountered by most physicians. Selective Serotonin Re-Uptake Inhibitors (SSRI’s) have become the most commonly prescribed antidepressants due to their superiority compared with other antidepressants in the treatment of acute major depression. Although exceedingly rare, hepatotoxicity resulting from sertraline use has been previously reported. In these case reports, the liver injury pattern was predominately hepatocellular. Unlike previous cases, we report the case of a patient presenting with markedly elevated cholestatic enzymes and painless jaundice while taking sertraline for treatment of depression.
Highlights
Depression is a very common disorder amongst the general population and frequently encountered by most physicians
Recent evidence suggests sertraline may be superior in efficacy, acceptability, and tolerability compared with other antidepressants in the treatment of acute major depression [2]
We report the case of a patient presenting with markedly elevated cholestatic enzymes and painless jaundice while taking sertraline for treatment of depression
Summary
Depression is a very common disorder amongst the general population and frequently encountered by most physicians. (2015) Sertraline Induced Acute Hepatitis: A Case Report. Asymptomatic elevations of transaminases have been documented in 0.8% of patients receiving sertraline [3]. A review of the literature revealed eleven prior reports of sertraline induced hepatotoxicity presenting with a predominately hepatocellular injury pattern or mixed obstructive and hepatocellular picture. Reported symptoms ranged from asymptomatic elevation of transaminases to fulminant hepatitis [4]-[7]. In these case reports, the liver injury pattern was predominately hepatocellular. We report the case of a patient presenting with markedly elevated cholestatic enzymes and painless jaundice while taking sertraline for treatment of depression. We reported a young female with obsessive-compulsive disorder treated with sertraline-developed sertraline induced acute hepatitis
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