Abstract
Thirty-two recipients of 33 renal allografts from related donors were divided into three groups by serotyping and genetic analysis. In the first group, eight patients inherited the same HL-A complexes as their donors. Seven have had excellent courses, with complete rehabilitation; one has recurrent glomerulonephritis. In the second group, seven patients inherited one HL-A complex in common with their donors and had very good serologic matches for the other. All had evidence of rejection, but six have had excellent courses; two have stable but subnormal function. In the third group 16 patients shared one HL-A complex with their donors but had poor serologic matches for the other; one differed by both complexes from his donor. Three patients have had excellent courses though two show decreasing creatinine clearances. Ten had unsatisfactory courses resulting in death, nephrectomy or poor rehabilitation; four have had intermediate courses. Intrafamilial donors can be selected so that the prognosis is excellent for rapid and complete rehabilitation.
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