Serotonin system and post-stroke depression

Abstract

Objective To investigate the effect of the 5-hydroxytryptamine (5-HT) on the occurrence, development of post-stroke depression (PSD). Methods The literatures on the relationship between 5-HT and PSD were selected from databases such as Wanfang Data , CNKI and PubMed before in 2010-2014. According to absorption and exclusion criteria of the literature, collect literatures, and summary, induce and analyze on them. Results Search 258 literatures and accept 44 literatures accorded with the criteria, including the relationship between 5-HT and PSD, the relationship between 5-hydroxytryptamine receptor (5-HTR) gene polymorphism and PSD, the relationship between 5-hydroxytryptamine transporter linked promoter region(5-HTTLPR) and PSD, and the treatment of selective serotonin reuptake inhibitors (SSRIs) in PSD. Conclusion Reduced levels of 5-HT lead to the occurrence of PSD, and they had a negative correlation; 5-HTR1A, 5-HTR2A are related genes of PSD; S allele and S/S genotype is susceptible factors of PSD, while the L allele is the protective factors of PSD; SSRIs can increase the level of 5-HT in the synaptic gap so as to improve the depressive symptoms of PSD. In the future, it is necessary to increase the sample size to confirm the relationship between 5-HT and PSD, and combine with other factors to explore the relationship between them. Key words: Serotonin; Post stroke depression; Gene polymorphism