Abstract
Synthesis of serotonin from tryptophan was measured in synaptosomes isolated from rat brainstem and diencephalon. Incubation with exogenous seroton adds only to small decreases in the rate of serotonin synthesis. Of several monoamine oxidase inhibitors examined only pheniprazine appeared to inhibit serotonin synthesis. This effect of pheniprazine was probably not mediated by monoamine oxidase inhibition and secondary feed-back inhibition by elevated levels of end-product. It is suggested that pheniprazine can inhibit the formation of both serotonin and catecholamines at the aromatic amino acid decarboxylase step.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
