Abstract
Case presentationAn 85-year-old woman with a history of depression treated with polypharmacy including selective serotonin reuptake inhibitor presented to the emergency department with head, and upper and lower limb tremors four hours after increasing the dose of quetiapine from 12.5 milligrams (mg) per day to 25 mg/day. She was diagnosed with serotonin syndrome (SS), and all medications except clotiazepam were discontinued. The symptoms subsided within 48 hours.DiscussionThe use of atypical antipsychotics alone seldom increases the risk of SS. However, combining atypical antipsychotics with serotonergic agents increases the risk of SS because the activity of serotonin receptor subtype 1A is relatively enhanced. This report suggests that physicians should be aware that even a small increase in quetiapine could pose a risk of developing SS.
Highlights
Combining atypical antipsychotics with serotonergic agents increases the risk of serotonin syndrome (SS) because the activity of serotonin receptor subtype 1A is relatively enhanced
This report suggests that physicians should be aware that even a small increase in quetiapine could pose a risk of developing SS. [Clin Pract Cases Emerg Med. 2021;5(3):365–366.]
She had a long history of major depressive disorder and insomnia, which were treated with escitalopram 20 milligrams per day, mirtazapine 30 mg/day, sulpiride 20 mg/day, olanzapine 2.5 mg/day, quetiapine 12.5 mg/day, and clotiazepam 5 mg/day
Summary
Case presentation: An 85-year-old woman with a history of depression treated with polypharmacy including selective serotonin reuptake inhibitor presented to the emergency department with head, and upper and lower limb tremors four hours after increasing the dose of quetiapine from 12.5 milligrams (mg) per day to 25 mg/day. She was diagnosed with serotonin syndrome (SS), and all medications except clotiazepam were discontinued.
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