Abstract
This study investigated the relationship between increased serotonin (5-hydroxytryptamine, 5HT) receptor sensitivity and human aggression. A low oral dose of meta-chlorophenylpiperazine (MCPP), a postsynaptics 5HT receptor agonist, was administered in a placebo-controlled design to depressed ( n = 22) and panic disorder ( n = 20) patients classified with or wothout signs of outwardly directed aggression, patients with a history of suicide attemps (inwardly directed aggression) ( n = 11), and normal controls ( n = 19). Hormones under 5HT control were measured at 30-min intervals. Results were as follows: (1) MCPP did not induce or reduce anger, (2) patients with outwardly directed aggression did not have significantly greater MCPP-induced cortisol or prolactin release than did patients without signs of outwardly directed aggression, (3) patients with a history of suicide attemps did not have significantly greater MCPP-induced cortisol or prolactin release than did normal controls, and (4) MCPP-induced hormone release was unrelated to measures of aggression.
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