Abstract
1. 1. The effect of serotonin (5-hydroxytryptamine; 5-HT) on the induction of long-term potentiation (LTP) in rat visual cortex was investigated by using slice preparations in vitro. 2. 2. Bath application of 5-HT (0.1–10 μM) did not affect the baseline synaptic potentials evoked by single-pulse test stimulation, but inhibited the induction of LTP in a concentration-dependent manner. 3. 3. The effect of 5-HT was blocked by the 5-HT 1 receptor antagonist pindolol or the 5-HT 2, 7 receptor antagonist ritanserin, but not by the 5-HT 3, 4 receptor antagonist MDL72222. 4. 4. These results suggest that 5-HT plays a role in suppressing the induction of LTP in the rat visual cortex.
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