Abstract
In rats subjected to immobilization stress for 5–150min, the concentration of serotonin was measured in the whole hypothalamus and in seven hypothalamic nuclei using a microdissection technique and a sensitive enzymatic-isotopic microassay. A significant increase in the concentration of serotonin was found in the whole hypothalamus after 15 and 30 min of immobilization, in the ventromedial and suprachiasmatic nuclei after all intervals studied, and in the median eminence and the dorsomedial nucleus only after some periods of immobilization. No changes in the concentration of serotonin were found in the supraoptic, paraventricular and arcuate nuclei. We suggest that increased levels of serotonin in the hypothalamic nuclei might reflect a role of this amine in the regulation of increased pituitary-adrenocortical activity under stress.
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