Abstract
Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries contained high levels of 5-HT (over 0.5 μg/g wet weight) and its metabolite, 5-hydroxyindoleacetic acid (over 0.6 μg/g wet weight); and a 5-HT-immunoreactive nerve plexus was demonstrated. The possible role of these nerves is discussed.
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