Abstract
Renal biopsy specimens of patients during the maintenance phase of ischemic acute tubular necrosis show evidence of fresh ischemic lesions, suggesting recurrent intermittent renal hypoperfusion. Some of these new ischemic lesions may be secondary to intermittent hypotension 1 Conger JD Hemodynamic factors in acute renal failure. Adv Ren Replace Ther. 1997; 4: 25-37 PubMed Google Scholar or to granulocyte and complement activation secondary to hemodialysis with so-called bioincompatible membranes. 2 Himmelfarb J Hakim RM The use of biocompatible membranes in acute renal failure. Adv Ren Replace Ther. 1997; 4: 72-80 PubMed Google Scholar Both mechanisms could contribute to further ischemic reperfusion injury and to prolongation of renal failure.
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