Serotonin and its role in dystonia: a systematic review

Abstract

Event Abstract Back to Event Serotonin and its role in dystonia: a systematic review Marenka Smit1*, Anna Bartels1, Martijn V. Faassen2, Anouk Kuiper1, Klary Niezen-Koning2, Ido Kema2, Rudi Dierckx3, Tom D. Koning4 and Marina Tijssen1 1 University Medial Center Groningen, Department of Neurology, Netherlands 2 University Medial Center Groningen, Department of Laboratory Medicine, Netherlands 3 University Medial Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Netherlands 4 University Medial Center Groningen, Department of Genetics, Netherlands Dystonia is a hyperkinetic movement disorder characterized by sustained or intermittent muscle contractions. Emerging data describe high prevalences of non-motor symptoms, including psychiatric co-morbidity, as part of the phenotype of dystonia. Basal ganglia serotonin and serotonin-dopamine interactions gain attention, as imbalances are known to be involved in extrapyramidal movement and psychiatric disorders. We systematically reviewed the literature for studies relating to serotonin and its role in dystonia. Involvement of serotonin in patients with dystonia is demonstrated by decreased levels of 5-hydroxyindolacetic acid, the main metabolite of serotonin. Furthermore, a relation between dystonia and drugs affecting the serotonergic system was described in 133 cases in 66 papers. Psychiatric co-morbidity or unclassified behavioral problems were described in several of the papers, but likely underestimated as it was not systematically examined. Currently, there are no good (pharmaco)therapeutic options for most forms of dystonia. Further research is required to establish the role of the serotonergic system in dystonia as therapeutic interventions influencing the serotonergic metabolism might be a new focus. Keywords: Dystonia, non-motor, Psychiatric disorder, neurotransmitters, Serotonin, 5-HIAA Conference: 5th Biennial Workshop on Dystonia: “Controversies in Dystonia and Parkinsonism” | Nobile Collegio Chimico Farmaceutico, Rome, May 29-30, 2015, Rome, Italy, 29 May - 30 May, 2015. Presentation Type: Poster presentation Topic: Dystonia Citation: Smit M, Bartels A, Faassen MV, Kuiper A, Niezen-Koning K, Kema I, Dierckx R, Koning TD and Tijssen M (2015). Serotonin and its role in dystonia: a systematic review. Front. Neurol. Conference Abstract: 5th Biennial Workshop on Dystonia: “Controversies in Dystonia and Parkinsonism” | Nobile Collegio Chimico Farmaceutico, Rome, May 29-30, 2015. doi: 10.3389/conf.fneur.2015.57.00002 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Apr 2015; Published Online: 27 Apr 2015. * Correspondence: Miss. Marenka Smit, University Medial Center Groningen, Department of Neurology, Groningen, Netherlands, m.smit03@umcg.nl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marenka Smit Anna Bartels Martijn V Faassen Anouk Kuiper Klary Niezen-Koning Ido Kema Rudi Dierckx Tom D Koning Marina Tijssen Google Marenka Smit Anna Bartels Martijn V Faassen Anouk Kuiper Klary Niezen-Koning Ido Kema Rudi Dierckx Tom D Koning Marina Tijssen Google Scholar Marenka Smit Anna Bartels Martijn V Faassen Anouk Kuiper Klary Niezen-Koning Ido Kema Rudi Dierckx Tom D Koning Marina Tijssen PubMed Marenka Smit Anna Bartels Martijn V Faassen Anouk Kuiper Klary Niezen-Koning Ido Kema Rudi Dierckx Tom D Koning Marina Tijssen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.