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Abstract
In purified striatal and cortical neurons in primary culture, serotonin (5-HT) stimulated basal cyclic AMP production (EC 50, 0.5 μM) 2.5- and 1.5-fold, respectively. The 5-HT 1 selective agonists, RU 24969 and 8-hydroxy-2- (di-n-propylamino)tetralin (PAT), did not stimulate cyclic AMP production. However, 5-HT, RU 24969 and PAT inhibited VIP-stimulated cyclic AMP formation in a dose-dependent manner. The actions of selective agonists and antagonists at 5-HT receptors mediating attenuation of cyclic AMP production suggest that they may be of the 5-HT 1 subtype.
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