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Abstract
The response to a sudden, severe loss of blood volume is complex and results in a drastic fall in arterial blood pressure and sympathoinhibition. The present study examines the distribution of serotonergic neurons in the caudal raphe involved in the mediation of the response to severe hemorrhage. Hemorrhage was performed in rats anesthetised with urethane by withdrawal of blood at a rate of 1 ml/min for approximately 4 min until blood pressure fell to 50 mm Hg. Sections through the brainstem were processed immunohistochemically to identify Fos, the protein product of the proto-oncogene c- fos expressed in the nucleus of neurons activated during the hemorrhage stimulus, and double-labeled to identify serotonin (5-hydroxytryptamine; 5-HT) content of cells. In response to hemorrhage, double-labeled Fos/5-HT neurons were located in the B3 region which includes the raphe magnus (RM) and its lateral extension. Hemorrhage-induced Fos-positive neurons that were not serotonergic were located in raphe pallidus (RP), parapyramidal cell group (PP), and the B3 region. Serotonergic neurons not activated by hemorrhage were located in the nucleus raphe pallidus, the parapyramidal cell group, the raphe obscurus (RO), and the B3 region. The specific rostrocaudal distribution of activated neurons may indicate different functions of groups of neurons in the response to hemorrhage.
Published Version
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