Abstract
The abdominal nerves of Rhodnius prolixus possess a serotonergic neurohaemal area. The uptake of [ 3H] serotonin and [ 3H] tryptophan into these abdominal nerves has been studied. There is a sodium-sensitive, high-affinity uptake mechanism for serotonin which has an apparent K m of 0.22 μM and a V max of 585 fmol/10 min. The loaded [ 3H] serotonin, identified by HPLC, is released in a calcium-dependent manner by high-potassium saline. [ 3H] tryptophan is also loaded, and about 1.4% of this is converted into serotonin over a 3 h incubation. The synthesised [ 3H] serotonin is also released by high-potassium in a calcium-dependent manner.
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