Serotonergic modulation of visual cortex plasticity.

Abstract

Event Abstract Back to Event Serotonergic modulation of visual cortex plasticity. Nathalie A. Lombaert1, Giel Schevenels1, Laetitia Aerts2, Ilse Smolders3, Geert Baggerman4 and Lutgarde Arckens1* 1 KU Leuven, Dept. of Biology, Belgium 2 KU Leuven, Dept. of Human Genetics, Belgium 3 VUB, Dept. of Pharmaceutical Chemistry and Drug Analysis, Belgium 4 UAntwerp, Dept. of Biology, Belgium We recently validated monocular enucleation (ME) of adult mice as a research model to investigate the anatomical, cellular and molecular mechanisms by which the mammalian brain compensates for the loss of sensory input, in this case visual input. The take-over of the brain regions originally dedicated to the lost sense, vision, by another intact sensory modality, somatosensation, is called cross-modal brain plasticity. A simple but powerful approach to induce changes in neuromodulator signaling is the social isolation (SI) paradigm (chronic mild stress). We recently observed that the plasticity phenomena which occur in the brain upon ME are abolished under the influence of SI, strongly suggesting the involvement of neuromodulators in cross-modal plasticity. Simultaneous HPLC analysis of the serotonin, dopamine and noradrenaline profile of visual and somatosensory cortex, areas involved in cross-modal plasticity, revealed an impact of SI and ME. Mass spectrometry-based identification and quantification of differentially expressed members of the plasma membrane proteome confirmed a role for serotonin signaling. Such cell-surface expressed proteins may serve as potent molecular entry points to steer cross-modal plasticity as a therapy for patients with sensory deficits. In vivo pharmacology to specifically modulate 5-HT1a, 5-HT2a or 5-HT3 receptor functioning is currently used to test this further. In sum, our data link serotonin signaling to cross-modal brain plasticity, opening up new opportunities for the treatment of sensory deficits. Keywords: Serotonin, Neuromodulation, Visual Cortex, brain plasticity, mouse model Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Neural Excitability, Synapses, and Glia: Cellular Mechanisms Citation: Lombaert NA, Schevenels G, Aerts L, Smolders I, Baggerman G and Arckens L (2019). Serotonergic modulation of visual cortex plasticity.. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00093 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Prof. Lutgarde Arckens, KU Leuven, Dept. of Biology, Leuven, 3000, Belgium, lut.arckens@kuleuven.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nathalie A Lombaert Giel Schevenels Laetitia Aerts Ilse Smolders Geert Baggerman Lutgarde Arckens Google Nathalie A Lombaert Giel Schevenels Laetitia Aerts Ilse Smolders Geert Baggerman Lutgarde Arckens Google Scholar Nathalie A Lombaert Giel Schevenels Laetitia Aerts Ilse Smolders Geert Baggerman Lutgarde Arckens PubMed Nathalie A Lombaert Giel Schevenels Laetitia Aerts Ilse Smolders Geert Baggerman Lutgarde Arckens Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.