Abstract
The effects of serotonin (5-hydroxytryptamine, 5-HT) on a transient outward potassium current ( I A) and on synaptically evoked IPSCs were simulated in a cerebellar granule cell (GC) model that included both feedforward and feedback inhibition. Responses of a GC to synaptic inputs of 10–100 Hz were evaluated. Serotonergic modulation of I A reduced the GC firing rate only at low input frequencies. By its actions on IPSC amplitude, 5-HT was able to reduce GC firing rate even at higher input frequencies. Thus, the additive effect of 5-HT on intrinsic and extrinsic membrane currents effectively resets the GC firing threshold to high-pass filter the input signal.
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