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Abstract
The effects of peripheral administration of the serotonin agonist zimeldine and the serotonin antagonist cyproheptadine reduced the amount of feeling and and water consumption were evaluated in domestic pigeons. Injections of zimeldine reduced the amount of feeding and drinking dose-dependently in 24-hr fasted animals. Administration of cyproheptadine enhanced food and water consumption dose-dependently up to a dose of 160 μg per 100 g body weight in nondeprived pigeons. Higher doses reduced ingestion probably due to a general behavioral depression. The effect of zimeldine was antagonized by cyproheptadine. It is concluded that, as in mammals, serotonin participates as an inhibitor in the regulation of feeding in birds. Contrary to the situation in mammals it has no activating effect on drinking but leads to a reduction of water consumption in pigeons.
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