Abstract
Extracellular serotonin in striatum was studied in untreated streptozotocin-induced diabetic rats and in untreated nondiabetic rats that served as age-, food-, and sex-matched controls. Extracellular serotonin was studied under anesthesia in vivo and dynamically with voltammetry. The results showed that an early and significant increase in extracellular serotonin occurred in striatum in the untreated acutely (3 days) diabetic rat. In untreated long-term (3–7 weeks) diabetic rats, however, the increase in serotonin in extracellular fluid in striatum decreased and returned to normal. The findings show a change in serotonergic function in acutely diabetic rats. The serotonergic alteration may have psychotherapeutic implications.
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