Abstract
[ 3H]MPP + had lower K m and higher V max values for its accumulation in rat brain synaptosomes than did [ 3H]MPTP. The kinetic parameters favored the uptake of [ 3H]MPP + in the striatum to that in hypothalamus, whereas they were equally favorable for the uptake of [ 3H]MPTP in both regions. Hypothalamic uptake of [ 3H]MPTP and [ 3H]MPP + was inhibited by desipramine, imipramine, norepinephrine, and serotonin. Striatal uptake of [ 3H]MPP + and [ 3H]MPTP was blocked by nomifensine and dopamine. These results support the concept that MPTP accumulates in serotonergic neurons where it is oxidized by monoamine oxidase B to MPP +, which is released and then is selectively accumulated in dopaminergic neurons via the dopamine uptake system.
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