Abstract
Abstract: The possible role of serotonin in modifying apomorphine‐induced stereotyped behaviour was investigated by studying the effects of methysergide and 5‐hydroxytryptophan on the threshold dosage of apomorphine required to induce stereotyped behaviour. The central serotonin antagonist methysergide potentiated apomorphine‐induced stereotyped behaviour, and 5‐hydroxytryptophan, the precursor of serotonin, inhibited apomorphine‐induced stereotyped behaviour. These results suggest that serotonin may play a role in the balance of neurotransmitters within the striatum that influence movements.
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