Abstract
Objective:To study the association between Protein energy malnutrition and polio-specific immunoglobulin G antibodies production among children in Gadap Town Karachi, Pakistan.Methods:Comparative cross sectional survey conducted at fixed EPI center and Pediatric OPD of a tertiary care hospital Karachi. Children were selected by convenient sampling method during the period from 17 March to 17 May 2013. It was ensured that they must have received more than seven oral polio vaccine doses as eligibility criteria for the study. A total of 170 blood samples were collected and tested for the presence of polio-specific IgG antibodies using Poliomyelitis IgG ELISA Test Kit produced.Results:Statistically significant relation was found between PEM and IgG antibodies production OR (P = 0.000). Overall Seroprevalence rate among the study population was 98.8%, PEM group 97.6% and healthy group 100%.Conclusion:The study demonstrated that there is a need to focus on the protein energy malnutrition among the children as an immunization strategy for the 100% seroprevalence rate in all population against polio in Pakistan.
Highlights
Disease eradication is long term sustainable management as compared to disease control and elimination program
Total 170 samples were tested for polio-specific IgG antibodies in which 168(98.8%) samples were positive and two subjects were seronegative
The high seroprevalence of 98.8% recorded in this study indicates children have effectively responded to the vaccine being used in the ongoing polio eradication initiative
Summary
Disease eradication is long term sustainable management as compared to disease control and elimination program. After successful small pox eradication, poliomyelitis is choice for eradication disease. While after Global polio eradication initiative program since 1988 mortality and morbidity due to polio has reduced, complete eradication of the polio would save more than forty billions of dollars globally. This income could be used for other public health program. This will be good for poor countries and give positive effect on public health program.[1]. Polio is almost eradicated except from three countries Pakistan, Nigeria and Afghanistan, India eradicated the polio in 2012.2 According to WHO independent monitoring report 2013: Pakistan is hardest country regarding polio eradication, in 2013 Pakistan had highest prevalence of polio
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