Seroprevalence of Toxoplasma gondii infection in sheep and goats from different geographical regions of the world: Systematic review and meta-analysis.

Abstract

The Toxoplasma gondii is an obligate intracellular protozoan parasite which significantly impact small ruminant productivity, international animal trade and transboundary movement of animal across the globe. The seroprevalence of T. gondii infection (toxoplasmosis) in sheep and goats is widely studied in many parts of the world and there is a lack of comprehensive information on prevalence estimates considering the global and regional perspectives. The aim of the study was to use systematic review and meta-analysis methods to estimate the global and regional pooled seroprevalence of T. gondii infection in sheep and goats, as well as factors that influence prevalence estimations. Relevant articles reporting the seroprevalence of toxoplasmosis in sheep and/goats were searched in five electronic databases, including PubMed, Web of Science, Scopus, Embase and ProQuest. After the publications were checked to verify they fit the inclusion criteria, a total of 225 articles were included in the systematic review and meta-analysis, reflecting data from 70 countries/regions. The pooled prevalence was estimated using a random effect meta-analysis model. Overall, the seroprevalence of T. gondii infection was 33.86% (95% CI: 30.47-37.25%) in sheep and 31.78% (95% CI: 28.99-34.58%) in goats, with significant variation in prevalence estimates across geographical locations (p<.001). Substantial heterogeneity (I2 >75%) was observed in most pooled seroprevalence estimates. The T. gondii infection in global sheep and goat population showed uptrend over the period. This information would be useful for epidemiologist, health authorities and farmers in order to plan future T. gondii survey and infection management strategies both locally and internationally.